Incredible nice bit of kit. The touch screen interface is amazing to use. It's a little bit heavy, the screen gets quite fingerprinty and is too big for what I need (I have a 1G nano) but that's about all.
The 2 finger pinch to resize photos is supercool and it's very quick switching from landscape to portrait when you turn it.
If it was the sort of thing I was after, I'd buy one in a heartbeat.
Assuming it has a standard 3.5 mm socket for headphones, you can connect it to the ST's aux in.. I would imagine that's as compatible as you could get.