welcome to the site
I've only had my ST a matter of weeks, but the vibration you are talking about doesnt sound normal to me. I had an ST170 prior to the Fiesta ST, and actual ride comfort they were about the same. I did a couple of hundred miles to Northamptonshire and back on Friday, and the car was fine - no aches or pains (and i've got a bad back atm!).
If you are getting excessive vibration, as people say get your wheel balance/tracking looked at, and also make sure your tyre pressures are correct (32 fronts, 29 backs).
The only thing I have noticed on the ST on longer journeys is road noise, which is louder than the Focus, however its a smaller car and I expected that.